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Date : 2010-06-22
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The p53 Family Cold Spring Harbor Perspectives in Biology ~ The p53 tumor suppressor pathway is inactivated in most cancers Delivery of p53 by gene therapy RNAi directed at p53 inhibitors and small molecules that target p53 are promising anticancer therapies that restore it
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The p53 Family ~ Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy Written and edited by experts in the field this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive review of the functions of the p53 family The contributors examine the normal roles of these transcription
The Origins and Evolution of the p53 Family of Genes ~ A common ancestor to the three p53 family members of human genes p53 p63 and p73 is first detected in the evolution of modern‐day sea anemones in which both structurally and functionally it acts to protect the germ line from genomic instabilities in response to stresses
The p53 family a subject collection from Cold Spring ~ Get this from a library The p53 family a subject collection from Cold Spring Harbor Perspectives in biology Arnold J Levine David Lane The p53 tumor suppressor genethe guardian of the genome protects cells against genotoxic stress but is mutated in many cancers It encodes one of a family of transcription factors p53 p63
p53 SpringerLink ~ The regulation of the p53mediated stress response by MDM2 and MDM4 In Levine AJ Lane D editors Cold spring harbor perspectives in biology volume on the p53 family
p53 Family Role of Protein Isoforms in Human Cancer ~ TP53 TP63 and TP73 genes comprise the p53 family Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells
The Simons Center for Systems Biology Research School ~ The Simons Center for Systems Biology Research Ak P Markert E Wang H Hu W PuzioKuter A Levine AJ 2010 The Origins and Evolution of the p53 Family of Genes The P53 Family Chapter 1 Cold Spring Harbor Perspectives in Biology Cold Spring Harbor Laboratory Press Hu W Chan CS Wu R Zhang C Sun Y Song JS Tang LH Levine AJ
P53 p63 p73 family Wikipedia ~ P53 p63 and p73 have similar features in their gene structures and functions but have also diverged evolutionarily The p53 family evolved from a p63p73 ancestor gene in invertebrates 4 P53 diverged from p63p73 with a gene duplication in the cartilaginous fish 4
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